PROFILE

SHORT BIOGRAPHY

My research project focused on the molecular mechanism in which the Calcium-Sensing Receptor (CaSR) forms a unique protein signaling complex in the presence of the cytoskeletal adaptor protein Homer-1c. My primary focus was on how this signaling complex promotes bone mass density in osteoblasts cells. In bone, the Homer-1c-dependent signaling pathway downstream of the CaSR supports calcium-dependent osteoblast survival and differentiation and thereby promotes bone formation. I have identified the minimum requirements of the signaling complex. A possible mechanism by which Homer1 could interact with the CaSR-dependent protein machinery that controls mTORC2 via the small G protein Rho was found. Activation of pAkt-S473 via a novel interaction between CaSR, Homer1 and mTORC2 may provide an alternative target for anabolic therapy for osteoporosis. The CaSR is a member of GPCR class C along with mGluRs and various other receptors which is a potential target of various pharmacological treatments.

 

Currently, I am working as a researcher at the University of Sydney, on a project that spans from animal (rodent) experiments through to molecular laboratory work. The study to date has used ~2500 mice, split into 21 diet treatments and investigates the influence of nutrition on healthy metabolic ageing. A study of this size has greatly sharpened my skills in data management and accurate record keeping, as well as fostered my overall project management experience. Additionally, my role involves collaborating with a multidisciplinary team of scientists, including biologists, biochemists, and statisticians, to analyze and interpret the data collected from the experiments. This has allowed me to develop strong communication and teamwork skills while gaining a deeper understanding of the scientific research process. Overall, my experience as a researcher has provided me with valuable insights into the field of nutrition and metabolic aging, making me well-equipped for future roles in this area.  

RESEARCH INTEREST

• Cellular Biochemistry
• Protein Biochemistry
• Molecular Biology,
• Nutrition and Physiology
• Analytical Biochemistry
• Clinical Biochemistry
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